The very first vaccine was for smallpox. It turned out to be a disaster, increasing the death rates and incidence of smallpox, while causing numerous serious side effects.
Likewise, the polio vaccine is widely credited for eliminating polio in this country, while in reality, the polio vaccine caused an increase in polio rates, which was hidden from the public by a redefinition of the polio disease. 
The number of vaccines, with the health damage and deaths they cause, continues to grow.
Many of those opposed to vaccines are not opposed to the idea of preventing disease through vaccination, but want vaccines that are both safe and effective. The pharmaceutical companies have been unable to provide a single safe and effective vaccine.