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New Science Study Results from University Hospital Described (Olive and grape seed extract prevents post-traumatic osteoarthritis damages and…

New Science Study Results from University Hospital Described (Olive and grape seed extract prevents post-traumatic osteoarthritis damages and exhibits in vitro anti IL-1 beta activities before and after oral consumption)

By a News Reporter-Staff News Editor at Science Letter — Investigators discuss new findings in Science. According to news reporting out of Nantes, France, by NewsRx editors, research stated, “Polyphenols exert a large range of beneficial effects in the prevention of age-related diseases. We sought to determine whether an extract of olive and grape seed standardized according to hydroxytyrosol (HT) and procyanidins (PCy) content, exerts preventive anti-osteoathritic effects.”

Our news journalists obtained a quote from the research from University Hospital, “To this aim, we evaluated whether the HT/PCy mix could (i) have in vitro anti-inflammatory and chondroprotective actions, (ii) exert anti-osteoarthritis effects in two post-traumatic animal models and (iii) retain its bioactivity after oral administration. Anti-inflammatory and chondroprotective actions of HT/PCy were tested on primary cultured rabbit chondrocytes stimulated by interleukin-1 beta (IL-1 beta). The results showed that HT/PCy exerts anti-inflammatory and chondroprotective actions in vitro. The preventive effect of HT/PCy association was assessed in two animal models of post-traumatic OA in mice and rabbits. Diet supplementation with HT/PCy significantly decreased the severity of post-traumatic osteoarthritis in two complementary mice and rabbit models. The bioavailability and bioactivity was evaluated following gavage with HT/PCy in rabbits. Regular metabolites from HT/PCy extract were found in sera from rabbits following oral intake. Finally, sera from rabbits force-fed with HT/PCy conserved anti-IL-1 beta effect, suggesting the bioactivity of this extract.”

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