Wikipedia: a Web of Deception

By Helen Buyniski and Gary Null

 

Wikipedia wants us to believe the entries in its “encyclopedia” are truthful, fair, and balanced. However, a comprehensive analysis of its nutritional articles reveals a plethora of factual inconsistencies and a clear and present bias against the very idea of nutritional supplementation. Even though almost every nutrient page admits most Americans don’t consume the Recommended Daily Allowance (RDA) of that particular vitamin or mineral, the pages’ editors still categorically discourage supplementation. Wikipedia’s main article on vitamins declares that supplements are “thought to be of little value in healthy people,”1 adding “no clear justification exists for recommending supplementation for preventing many diseases” with vitamin D, so much so that “further research of similar design is unneeded in these areas.”2 That certainly sounds final.

Wikipedia would have you believe the science is 100% settled on nutritional supplements, but what are their qualifications for making such declarations? Attempts by qualified professionals with over 40 years of experience in the nutritional field to edit these articles to reflect accurate information are merely changed back in accordance with the beliefs of the core group of Skeptics who exercise an iron grip on Wikipedia’s health and nutritional pages. Editors, whose qualifications are lacking, are nevertheless given free rein to lead readers astray who might otherwise find information beneficial in their search for better health.

A thorough study of thousands of scientific articles in peer-reviewed literature suggests that the Skeptics controlling the flow of information aren’t telling us everything we need to know, whether about the negative effects of consuming too little or the benefits of supplementing with these nutrients. Wikipedia and its co-founder Jimmy Wales have much to answer for. Their insistence on replacing the truth with inaccurate, scientifically-reductionist Skepticism is contributing to global ignorance.

Here are just a few facts you won’t find in the Wikipedia entries for essential vitamins and minerals, randomly selected from hundreds of thousands of scientific research papers whose conclusions contradict those of the Wikipedia cognoscenti.

Vitamin A

The National Institutes of Health’s global database of peer-reviewed medical literature, PubMed, turns up 52,337 articles on vitamin A. A sampling of those articles indicates a wealth of beneficial effects associated with this micronutrient. The journal Nutrients discusses the positive effects of vitamin A on the immune system, extending to reduced mortality associated with diarrhea, measles, meningitis, and other illnesses endemic to third-world populations.3 The Journal of Molecular Neuroscience details multiple pathways of action for vitamin A for treating multiple sclerosis.4 A Lancet study demonstrates reduced incidence of malaria among children treated with vitamin A supplementation in Papua New Guinea.5

Vitamin A also:

Protects against night blindness6

Protects against age-related macular degeneration7

Aids in bone and tooth development8

Has a protective effect against squamous cell carcinoma9

Vitamin B1 (Thiamine)

PubMed lists 16,004 studies on the effects of thiamine. Advances in Nutrition discusses thiamine’s role in protecting against dementia, along with the other B vitamins and in conjunction with vitamins C and E.10 Cardiovascular Drugs and Therapy recommends thiamine supplementation to improve outcomes in patients with heart failure.11 A study in Congestive Heart Failure links thiamine to improvements in cardiac function, weight loss, urine output, and the symptoms of heart failure.12 Case Reports in Neurological Medicine found a strong link between thiamine supplementation and improvements in cluster headaches.13

Thiamine also:

Plays a central role in the production of RNA and DNA14

Improves cognitive performance in individuals with Alzheimer’s15

Reduces cell proliferation in breast cancer16

Protects against pulmonary hypertension17

Vitamin B2 (Riboflavin)

PubMed reveals 17,529 articles concerning the effects of riboflavin. The substance has been shown to produce many health benefits. The publication Headache analyzes riboflavin’s action in modulating mitochondrial metabolic abnormalities, alleviating migraine symptoms and pointing toward classification of migraine as a mitochondrial disorder.18 The journal Electrophoresis demonstrates riboflavin’s ameliorative effect on muscle weakness linked to dysfunctional mitochondrial metabolism,19 and Aging magazine evaluated riboflavin’s potential in cancer therapy with DPI, which blocks mitochondrial respiration without permanently damaging the cells.20

Riboflavin also:

Plays an integral role in cellular respiration and metabolism21

Relieves oxidative stress and insulin resistance in diabetes22

Protects against neurodegenerative and cardiovascular diseases23

Protects against anemia and thyroid dysfunction24

Vitamin B3 (Niacin)

Niacin appears in the PubMed literature in 13,061 articles. A sampling of this research reveals widespread clinical benefits stemming from this nutrient. Biomedical Pharmacotherapy outlined the therapeutic benefits of niacin supplementation in alleviating oxidative stress and insulin resistance in diabetes.25 International Journal of Tryptophan Research outlines the role of niacin (as nicotinamide) in protecting neurons from traumatic injury, stroke, Alzheimer’s, Parkinson’s, and Huntington’s disease.26 The journal Nutrients details the use of high-dose niacin supplementation to successfully treat bipolar disorder.27

Niacin also:

Protects against brain injury during cardiac arrest28

Increases insulin sensitivity and moderates negative effects of high-fat diet29

Maintains genetic stability and repairs DNA30

Alleviates psychotic symptoms in schizophrenia31

Vitamin B5 (Pantothenic Acid)

Ever the naysayer, Wikipedia states that “although pantothenic acid supplementation is under preliminary research for a variety of human diseases, there is insufficient evidence to date that it has any effect.”32 However, there is an abundance of evidence – pantothenic acid is referenced in 3,347 articles on PubMed. Its effects are numerous, as it is the precursor to co-enzyme A, a biomolecule involved in over 70 enzymatic pathways. International Journal for Vitamin and Nutrition Research reveals that pantothenic acid (as calcium D-pantothenate) improves healing in flesh wounds.33 Vascular Health and Risk Management cites pantothenic acid (as pantethine)’s effectiveness in reducing cholesterol levels and other cardiovascular risk markers.34 Expert Review of Clinical Pharmacology describes the protective effects of pantothenic acid against valproic acid-induced hepatotoxicity linked to increased oxidative stress.35

Pantothenic Acid also:

Plays a crucial role in the metabolism of fats and carbohydrates36

Is integral to protein synthesis/amino acid catabolism37

Protects against atherosclerosis38  

Ameliorates oxidative stress in radiation damage39

Vitamin B6  (Pyridoxine)

Pyridoxine is mentioned in 9,893 articles on PubMed. The substance has numerous beneficial effects across human cellular systems. The journal Cellular and Molecular Biology illuminates pyridoxine’s protective effects against Alzheimer’s disease, citing the vitamin’s antioxidant property as the active mechanism.40 Anticancer Research shows pyridoxine’s potential role in treating malignant melanoma.41 Food and Chemical Toxicology demonstrates pyridoxine’s protective effect against acetaminophen-induced hepatotoxicity, enacted through suppression of oxidative stress and induction of antioxidant enzymes.42

Pyridoxine also:

Is an essential component of amino acids, carbohydrates, and lipids43

Relieves morning sickness in pregnant women44

Plays a role in neurotransmitter synthesis and hemoglobin formation45

Protects against seizures, migraine, chronic pain, and depression46

Vitamin B7 (Biotin)

“Biotin is often recommended as a dietary supplement for strengthening hair and nails, though scientific data supporting these outcomes are weak,” says Wikipedia.47 Not quite – biotin is referenced in 31,208 articles on PubMed, which show systemic benefits extending far beyond hair and nails. The journal Cutis describes a marked improvement in nail health among subjects taking biotin supplements.48 Journal of Nutritional Biochemistry outlines biotin’s potential in treating diabetes, hyperglycemia, and hyperlipidemia based upon its improvement of glucose tolerance and promotion of glucose and lipid homeostasis.49 Multiple Sclerosis reveals that high-dose biotin supplementation produces sustained reversal of multiple sclerosis.50

Biotin also:

Influences the mediation of gene expression51

Plays a key role in cell metabolism, growth, and differentiation52

Shows potential as a gene-based cancer therapy and delivery system53

Regulates immunological and inflammatory functions54

Vitamin B9 (Folate)

PubMed lists 56,178 studies that mention folate. The benefits of Folate supplementation are so well known that over 50 countries fortify certain foods with the nutrient to ensure adequate consumption by their population. American Journal of Clinical Nutrition reveals a decreased breast cancer risk associated with higher folate intake in postmenopausal women.55 Journal of Gastroenterology and Hepatology similarly finds a decreased risk of esophageal and pancreatic cancers associated with folate consumption.56 Biotechnic and Histochemistry shows that folic acid supplementation mitigates the toxic effects of bisphenol-A in testes.57

Folate also:

Prevents neural tube defects in utero when taken during early pregnancy58

Decreases risk of stroke and cardiovascular disease59

Promotes wound healing60

Is integral to cell division and growth, particularly during infancy and pregnancy61

Vitamin B12

PubMed lists 30,510 studies mentioning vitamin B12. Supplementation is mandated in vegans and vegetarians because B12 is only found in animal proteins. Nevertheless, the literature is full of side benefits to such supplementation. The Journal of the Neurological Sciences shows that B12 supplementation has a protective effect against multiple sclerosis progression.62 Maternal and Child Health Journal finds that maternal vitamin B12 supplementation leads to higher expressive language scores in children at 30 months.63 Diabetes Care suggested vitamin B12 supplementation improved outcomes for elderly diabetic individuals presenting with neuropathy and posited oxidative stress as the culprit in declining B12 levels.64

Vitamin B12 also:

Plays a central role in myelin formation65

Protects against pernicious anemia and associated psychiatric symptoms66

Reduces oxidative stress and lessens its negative effects on the nervous system67

Protects against Alzheimer’s and vascular dementia68

Vitamin C

There are 65,550 articles on vitamin C on PubMed. Picking out a few of these reveals a wide range of health benefits associated with the substance. The journal Nutrients discusses the well-known role of vitamin C supplementation in preventing and lessening the duration of the common cold (which Wikipedia denies).69 The European Journal of Cell Biology discusses vitamin C (as L-ascorbate)’s cancer-fighting properties, specifically in colorectal cancer.70 Wikipedia categorically denies any anti-cancer effects in the nutrient, dismissing the reams of studies in the scientific literature as “observational and uncontrolled studies.” CNS Neuroscience and Therapeutics analyzes vitamin C’s antioxidant actions in the central nervous system and how these processes inhibit the onset of neurodegenerative diseases like Alzheimer’s and Parkinson’s.71

Vitamin C also:

Plays a central role in immune system function72

Prevents scurvy73

Indicates promise as a non-toxic cancer treatment74

Facilitates iron absorption75

Vitamin D

There are 77,269 articles on vitamin D available on PubMed, making it the most studied vitamin. Just a glimpse at the literature shows numerous benefits associated with this micronutrient. American Journal of Public Health surveys decades of studies, revealing a strong correlation between vitamin D and its metabolites with reduced risk and decreased mortality from colorectal, breast, prostate, and ovarian cancers.76 The British Journal of Psychiatry discusses the positive effects of vitamin D supplementation on depressed patients.77 Nutritional Neuroscience illuminates the link between low serum levels of vitamin D and autism spectrum disorder, then demonstrates that vitamin D supplementation leads to improvement on behavioral and language metrics in children with ASD.78

Vitamin D also:

Protects against development of multiple sclerosis (and ameliorates symptoms in patients with MS)79

Strengthens bones and protects against osteoporosis/osteomalacia80

Protects against development of type I diabetes; increases insulin sensitivity in type II diabetes81

Improves cardiac function post-myocardial infarction82

Vitamin E

Wikipedia states, “Population studies suggested that people who consumed foods with more vitamin E, or who chose on their own to consume a Vitamin E dietary supplement, had lower incidence of cardiovascular diseases, cancer, dementia, and other diseases, but placebo-controlled clinical trials could not always replicate these findings.”83 Never satisfied with anything less than perfect replication, the Skeptic editors overlook the 41,453 studies referencing vitamin E in PubMed on their elusive quest for the perfect clinical trial. Nutrients, in a comprehensive survey of studies on the subject, points to the beneficial effects of vitamin E supplementation on Alzheimer’s disease and dementia, suggesting the mechanism of action extends beyond its antioxidant capabilities to its role in signaling, membrane fluidity and gene regulation.84 The International Journal for Vitamin and Nutrition Research discusses the neuroprotective capabilities of vitamin E against glutamate cytotoxicity in neuronal cells.85 Atherosclerosis reveals that vitamin E supplementation is effective in reducing mortality and atherosclerosis only when subjects consume a low-fat, low-cholesterol diet – subjects consuming the Standard American Diet had no such luck.86

Vitamin E also:

Regulates enzyme activity and gene expression87

Shows promise (as tocotrienol) as a non-toxic anticancer treatment88

Lowers cholesterol89

Protects against neurodegeneration90

Vitamin K

Vitamin K is referenced in 24,421 studies on PubMed, but none of those studies are good enough for Wikipedia, which states that “vitamin K has been promoted in supplement form with claims it can slow tumor growth; however, no good medical evidence supports such claims.”91 Archives of Physiology and Biochemistry shows beneficial effects from high-dose vitamin K supplementation (in combination with Calcium) in treatment of liver cancer.92 Pol Merkur Lekarski recommends a constant concentration of vitamin K in the diet to prevent complications arising from continued dosage of hydroxycoumarin derivatives. 93The medical journal Biofactors details the role of vitamin K in synthesizing sphingolipids, a class of structural lipids that in addition to shaping brain cell membranes also play a significant part in proliferation, differentiation, cell-cell interactions, and senescence.94

Vitamin K also:

Is needed to synthesize proteins involved in blood clotting95

Plays a key role in cognition and behavior96

Slows the development of soft tissue calcification in uremia97

Prevents vascular calcification98

Calcium

Wikipedia calls calcium supplementation “controversial” but admits that since 2010, the FDA has permitted the health claim that calcium and vitamin D supplements together protect against osteoporosis. Qualified health claims regarding the mineral’s effectiveness in reducing the risks of colon cancer and hypertension are also permitted.99 A PubMed search yields 563,919 results for calcium and the nutrient is ubiquitous in bodily processes. European Journal of Nutrition confirms calcium’s effectiveness in improving bone mineral density in teenage girls.100 Public Health Nutrition adds that in addition to its preventive benefits against the disease, calcium reduces the rate of bone loss in patients who already have osteoporosis.101 New England Journal of Medicine finds calcium supplementation reduces the risk of recurrent colorectal adenomas.102

Calcium also:

Plays a central role in blood cell synthesis103

Protects against stroke, especially in conjunction with magnesium and potassium104

Contributes to bone growth and development105

Lowers blood cholesterol106

Copper

Copper is mentioned in 118,869 studies on PubMed. Metallomics discusses copper’s possible role in treating cancer as an alternative to platinum-based chemotherapy drugs.107 The journal Nutricion Hospitalaria finds a significant protective role for copper against cognitive and physical disabilities in the elderly obese.108 Drug and Chemical Toxicology shows the protective antioxidant effects of copper (in combination with nicotinate) on the kidneys in the presence of glycerol.109

Copper also:

Protects against anemia110

Plays a key role in neurotransmitter synthesis111

Shows strong potential in chelation treatment for neurodegenerative disorders112

Iodine

Iodine appears in 112,753 studies on PubMed. Nationwide insufficient iodine was once considered such a serious problem that the mineral was added to table salt, and iodine deficiency remains the leading cause of preventable mental retardation in the world today, even in developed nations. But don’t look towards Wikipedia to recommend an iodine supplement. Journal of Nutritional Biochemistry finds that iodine supplementation in utero improves motor coordination in offspring.113 Molecular Medicine discusses iodine’s antitumor effects on several cancers, including prostate.114

Iodine also:

Is required for synthesis of thyroid hormones115

Plays a central role in fetal brain development116

Prevents goiter117

Protects against cognitive decline in the elderly118

Iron

A PubMed search yields 200891 studies referencing iron. Because the mineral is so important to sustaining life, and because iron deficiency is the world’s most common mineral deficiency, many foods are already fortified with iron. Supplementation is another means of ensuring adequate iron consumption. Lakartidningen notes iron supplementation is used to treat inflammatory bowel disease.119

Iron also:

Prevents anemia120

Is required for the production of red blood cells121

Has anti-inflammatory properties122

Magnesium

Magnesium is referenced in 102,117 studies on PubMed. Given that the mineral is required for the catalytic action of over 300 enzymes, its effects are extensive across all bodily systems. The journal Diabetes Care finds that magnesium supplementation improved insulin response and glucose handling in elderly and non-insulin-dependent diabetics. The journal Diabetes Care reveals that magnesium supplementation protects against the development of Type II Diabetes in men and women, particularly in overweight individuals.123 Stroke journal discusses the benefits of magnesium supplementation in treating eclampsia and preeclampsia,124 while Nutrients finds higher magnesium intake correlates with lower risk of coronary heart disease.125

Magnesium also:

Has a beneficial effect on migraine126

Protects against high blood pressure127

Plays crucial role in DNA and RNA synthesis128

Has beneficial effect on depression and anxiety129

Potassium

Potassium appears in 251,138 studies in PubMed. Even Wikipedia admits that half of Americans do not meet potassium’s RDA requirement,130 and the article refrains from the site’s usual blanket dismissal of supplementation. Journal of Hypertension reveals significant benefits of potassium supplementation in treating hypertension.131

Potassium also:

Maintains fluid and electrolyte balance132

Plays an important role in hormone secretion and regulation133

Normalizes heart rhythms134

Governs muscle contraction135

Selenium

While Wikipedia cautions that “selenium supplementation has not succeeded in reducing the incidence of any disease, nor has a meta-analysis of such selenium supplementation studies detected a decrease in overall mortality,”136 selenium appears in 32,412 studies in PubMed, many of which would beg to differ. Mechanisms of Aging and Development outlines selenium’s protective effect against the onset of age-associated neurodegenerative disorders such as Parkinson’s, Alzheimer’s, and epilepsy.137 American Journal of Physiology discusses selenium’s beneficial effects on inflammatory bowel disease (IBD).138 Biological Trace Element Research outlines selenium’s role in protecting against malignant gliomas, both independently and alongside traditional chemotherapies.139

Selenium also:

Plays an important role in initiating and regulating immune responses140

Modulates inflammation and maintains gut homeostasis141

Demonstrates positive effect on liver, prostate, colorectal and lung cancers142

Reduces mortality in patients with septic shock143

Zinc

Zinc is referenced in 136,705 PubMed articles. The American Journal of Clinical Nutrition shows that zinc supplementation is correlated with better skin healing outcomes in burn patients.144 Another study in American Journal of Clinical Nutrition demonstrates that zinc supplementation is beneficial in improving immune function in the elderly, specifically T cell function.145 The prestigious journal Pediatrics shows zinc supplementation reduces the incidence and recurrence of severe diarrhea in children.146 Behavioral Brain Research indicates that zinc supplementation has a positive effect on cognitive performance, specifically in short- and long-term recognition memory and spatial working memory.147

Zinc also:

Lessens severity and duration of pneumonia148

Shortens the duration of the common cold149

Improves glycemic control in Type II Diabetes150

 

This does not represent an exhaustive list of vitamins and minerals, merely a sampling of nutrients where the scientific literature sharply contradicts Wikipedia’s claims regarding the uselessness of nutritional supplements. Wikipedia presents itself as the final authority on nutrition with its entries. However, hundreds of thousands of studies suggest that not only are most Americans deficient in many of these nutrients but that healthy individuals can also benefit from supplementing their intake. What responsibility do the ultra-Skeptic Wikipedia editors bear for discouraging readers from taking supplements that could markedly improve their health and quality of life? Why are they so determined to discourage the consumption of nutritional supplements? Why are nutritional supplements held to a higher standard of proof than other scientific theories and particularly pharmaceutical drugs, which go unmolested in Wikipedia’s pages despite less research backing them up?

In general, adults consuming a Standard American Diet take in markedly less than the RDA of the essential vitamins and minerals even as they consume too many calories overall. They thereby put themselves at greater risk of cellular weakness and disease, depending on which nutrients they lack. Even the adequacy of RDA-level consumption as a national standard for nutrition is questionable. Many European countries recommend higher levels of the essential nutrients for optimal health. Supplementation is a cheap and easy way to make up for dietary deficiencies, avoiding negative health repercussions and maximizing the benefits of these essential nutrients. By discouraging such an inexpensive and sensible route to mental and physical health, the arch-Skeptic editors on Wikipedia are leading readers astray. They must answer for their inaccurate presentation of the nutritional landscape and the repercussions it has for readers’ health.

The single most important factor in evaluating the nutritional science is how the information is used. Clinicians, doctors, nurses and other medical professionals are using the information contained in these thousands of scientific studies to treat patients – to improve their health and improve their lives by integrating nutritional supplements into their practices. Wikipedia and Jimmy Wales are doing nothing of the sort. To deny the benefits of clinical experience is to deny the basis of all treatment programs. Wikipedia and Jimmy Wales’ scientific-reductionist edifice is based on no qualifications, no experience, and no real-world application of the knowledge they claim to possess, and this is the Achilles’ heel of the skeptic approach. Discounting the clinical real-life experience of experienced medical professionals in favor of unfounded assertions from individuals who have never attempted to apply their opinions in the field shows the worst kind of bias.

 

FOOTNOTES

  1. Wikipedia. “Vitamin.” Accessed 19 Aug 2018. https://en.wikipedia.org/wiki/Vitamin
  2. Wikipedia, “Vitamin D.” Accessed 19 Aug 2018. https://en.wikipedia.org/wiki/Vitamin_D
  3. Wirth, JP et.al. Vitamin A Supplementation Programs and Country-Level Evidence of Vitamin A Deficiency. Nutrients.2017 Feb 24;9(3). https://www.ncbi.nlm.nih.gov/pubmed/28245571

4 Abdolahi, M. et. al. Molecular Mechanisms of the Action of Vitamin A in Th17/Treg Axis in Multiple Sclerosis. J Mol Neurosci. 2015 Dec;57(4):605-13. https://www.ncbi.nlm.nih.gov/pubmed/26319266.

 

5 Shankar, AH et.al. Effect of vitamin A supplementation on morbidity due to Plasmodium falciparum in young children in Papua New Guinea: a randomised trial. Lancet. 1999 Jul 17;354(9174):203-9. https://www.ncbi.nlm.nih.gov/pubmed/10421302

6 CRUZ, S. et.al.  Impact of Vitamin A Supplementation on Pregnant Women and on Women Who Have Just Given Birth: A Systematic Review. J Am Coll Nutr. 2018 Mar-Apr;37(3):243-250. https://www.ncbi.nlm.nih.gov/pubmed/29087239

7 Evans, J. et.al. Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration. Cochrane Database Syst Rev. 2012 Nov 14;11:CD000254. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD000254.pub3/full

8 Sahyoun, NR et.al. Nutritional status of the older adult is associated with dentition status. J Am Diet Assoc. 2003 Jan;103(1):61-6. https://www.ncbi.nlm.nih.gov/pubmed/12525795

9 Moon, TE. Effect of retinol in preventing squamous cell skin cancer in moderate-risk subjects: a randomized, double-blind, controlled trial. Southwest Skin Cancer Prevention Study Group. Cancer Epidemiol Biomarkers Prev. 1997 Nov;6(11):949-56. https://www.ncbi.nlm.nih.gov/pubmed/9367069

10 Fenech, M. Vitamins Associated with Brain Aging, Mild Cognitive Impairment, and Alzheimer Disease: Biomarkers, Epidemiological and Experimental Evidence, Plausible Mechanisms, and Knowledge Gaps. Adv Nutr. 2017 Nov 15;8(6):958-970. https://www.ncbi.nlm.nih.gov/pubmed/29141977

11 Kattoor, AJ et.al. Thiamine Therapy for Heart Failure: a Promise or Fiction? Cardiovasc Drugs Ther (2018). https://link.springer.com/article/10.1007%2Fs10557-018-6808-8

12 DiNicolantonio, JJ et.al. Thiamine Supplementation for the Treatment of Heart Failure: A Review of the Literature. Congest Heart Fail. 2013 Jul-Aug;19(4):214-22. https://www.ncbi.nlm.nih.gov/pubmed/23910704

13 Antonio, Constantino, et al. Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache. Case Reports in Neurological Medicine. 2018 Apr 18;2018:3901619 https://www.ncbi.nlm.nih.gov/pubmed/29850313

14 Kerns, J. Thiamin. Adv Nutr. 2017 Mar; 8(2):395-397. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347104/

15 Luong, KV et.al. Role of thiamine in Alzheimer’s disease.  Am J Alzheimers Dis Other Demen. 2011 Dec;26(8):588-98. https://www.ncbi.nlm.nih.gov/pubmed/22218733

16 Liu, X et.al. The effects of thiamine on breast cancer cells. Molecules. 2018 Jun 16;23(6). https://www.ncbi.nlm.nih.gov/pubmed/29914147

17 Asakura, T. et.al. Thiamine-responsive pulmonary hypertension. BMJ Case Rep. 2013 Jan 8;2013. https://www.ncbi.nlm.nih.gov/pubmed/23302552

18 Markley, HG. CoEnzyme Q10 and riboflavin: the mitochondrial connection. Headache. 2012 Oct;52 Suppl 2:81-7. https://www.ncbi.nlm.nih.gov/pubmed/23030537

19 Gianazza, E. Coordinated and reversible reduction of enzymes involved in terminal oxidative metabolism in skeletal muscle mitochondria from a riboflavin-responsive, multiple acyl-CoA dehydrogenase deficiency patient. Electrophoresis. 2006 Mar;27(5-6):1182-98. https://www.ncbi.nlm.nih.gov/pubmed/16470778

20 Oszvari, B. et.al. Targeting flavin-containing enzymes eliminates cancer stem cells (CSCs), by inhibiting mitochondrial respiration: Vitamin B2 (Riboflavin) in cancer therapy. Aging (Albany NY). 2017 Dec 16;9(12):2610-2628. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764395/

21 Udhayabanu, T. et.al. Riboflavin Responsive Mitochondrial Dysfunction in Neurodegenerative Diseases. J Clin Med. 2017 May 5;6(5). https://www.ncbi.nlm.nih.gov/pubmed/28475111

22 Alam, MM et.al. Ameliorative effect of riboflavin on hyperglycemia, oxidative stress and DNA damage in type-2 diabetic mice: Mechanistic and therapeutic strategies. Arch Biochem Biophys. 2015 Oct 15;584:10-9. doi: 10.1016/j.abb.2015.08.013. Epub 2015 Aug 28. https://www.ncbi.nlm.nih.gov/pubmed/26319175

23 Udhayabanu, op.cit.

24 Bhusal, A. et.al. Riboflavin Deficiency. StatPearls. 2017 Nov 29. https://www.ncbi.nlm.nih.gov/pubmed/29262062

25 Abdullah, KM et.al. Therapeutic effect of vitamin B3 on hyperglycemia, oxidative stress and DNA damage in alloxan induced diabetic rat model.  Biomed Pharmacother. 2018 Sep;105:1223-1231. https://www.ncbi.nlm.nih.gov/pubmed/30021358

26 Fricker, R. et.al. The Influence of Nicotinamide on Health and Disease in the Central Nervous System. Int J Tryptophan Res. 2018 May 21;11:1178646918776658. https://www.ncbi.nlm.nih.gov/pubmed/29844677

27 Jonsson, BH. Nicotinic Acid Long-Term Effectiveness in a Patient with Bipolar Type II Disorder: A Case of Vitamin Dependency. Nutrients. 2018 Jan 27;10(2). https://www.ncbi.nlm.nih.gov/pubmed/29382049

28 Kwon, WY et.al. Niacin suppresses the mitogen-activated protein kinase pathway and attenuates brain injury after cardiac arrest in rats. Crit Care Med. 2013 Sep;41(9):e223-32. https://www.ncbi.nlm.nih.gov/pubmed/23648567

29 Linke, A. et.al. Effects of extended-release niacin on lipid profile and adipocyte biology in patients with impaired glucose tolerance. Atherosclerosis. 2009 Jul;205(1):207-13. https://www.ncbi.nlm.nih.gov/pubmed/19131065

30 Kirkland, JB. Niacin Requirements for Genomic Stability. Mutat Res. 2012 May 1;733(1-2):14-20. https://www.ncbi.nlm.nih.gov/pubmed/22138132

31 Xu, XJ et.al. Niacin-respondent subset of schizophrenia – a therapeutic review. Eur Rev Med Pharmacol Sci. 2015;19(6):988-97. https://www.ncbi.nlm.nih.gov/pubmed/25855923

32 Wikipedia, “Pantothenic Acid.” Accessed 19 Aug 2018. https://en.wikipedia.org/wiki/Pantothenic_acid

33 Weimann, H. Studies on Wound Healing: Effects of Calcium D-Pantothenate on the Migration, Proliferation and Protein Synthesis of Human Dermal Fibroblasts in Culture. Int J Vitam Nutr Res. 1999 Mar;69(2):113-9. https://econtent.hogrefe.com/doi/10.1024/0300-9831.69.2.113

34 Evans, M. et.al. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation. Vasc Health Risk Manag. 2014 Feb 27;10:89-100. https://www.ncbi.nlm.nih.gov/pubmed/24600231

35 Felker, D. Evidence for a potential protective effect of carnitine-pantothenic acid co-treatment on valproic acid-induced hepatotoxicity. Expert Rev Clin Pharmacol. 2014 Mar;7(2):211-8. https://www.ncbi.nlm.nih.gov/pubmed/24450420

36 Leonardi, R. et.al. Biosynthesis of Pantothenic Acid and Coenzyme A. Ecosal Plus. 2007 Aug 13. http://www.asmscience.org/content/journal/ecosalplus/10.1128/ecosalplus.3.6.3.4

37 Leonardi, op.cit.

38 Jung, S. et.al. The long-term relationship between dietary pantothenic acid (vitamin B5) intake and C-reactive protein concentration in adults aged 40 years and older. Nutr Metab Cardiovasc Dis. 2017 Sep;27(9):806-816. https://www.ncbi.nlm.nih.gov/pubmed/28739188

39 Sm, S. et.al. Curative role of pantothenic acid in brain damage of gamma irradiated rats. Indian J Clin Biochem. 2018 Jul;33(3):314-321. https://www.ncbi.nlm.nih.gov/pubmed/30072831

40 Li, C. et.al. Pyridoxine exerts antioxidant effects in cell model of Alzheimer’s disease via the Nrf-2/HO-1 pathway. Cell Mol Biol (Noisy-le-grand). 2018 Jul 30;64(10):119-124. https://www.ncbi.nlm.nih.gov/pubmed/30084803

41 Shultz, TD et.al. Effect of pyridoxine and pyridoxal on the in vitro growth of human malignant melanoma. Anticancer Res. 1988 Nov-Dec;8(6):1313-8. https://www.ncbi.nlm.nih.gov/pubmed/3218963

42 Roh, Taehyun. Detoxifying effect of pyridoxine on acetaminophen-induced hepatotoxicity via suppressing oxidative stress injury. Food and Chemical Toxicology. 2018 Apr;114;11-22. https://www.sciencedirect.com/science/article/pii/S0278691518300826

43 Wu, XY et.al. Vitamin B6 deficiency, genome instability and cancer. Asian Pac J Cancer Prev. 2012;13(11):5333-8. https://www.ncbi.nlm.nih.gov/pubmed/23317180

44 Koren, Gideon et.al. Effectiveness of doxylamine-pyridoxine for morning sickness. American Journal of Obstetrics & Gynecology. 2016 May; 2014(5):664-666. https://www.ajog.org/article/S0002-9378(16)00236-2/fulltext

45 Brown, MJ et.al. Vitamin, B6 (Pyridoxine), Deficiency. StatPearls. 2017 Dec 8. https://www.ncbi.nlm.nih.gov/pubmed/29261855

46 Malouf, R. et.al. The effect of vitamin B6 on cognition. Cochrane Database Syst Rev. 2003;(4):CD004393. https://www.ncbi.nlm.nih.gov/pubmed/14584010

47 Wikipedia, “Biotin.” Accessed 19 Aug 2018. https://en.wikipedia.org/wiki/Biotin

48 Hochman, LG et.al. Brittle nails: response to daily biotin supplementation. Cutis. 1993 Apr;51(4):303-5. https://www.ncbi.nlm.nih.gov/pubmed/8477615

49 Fernandez-Mejia, Cristina. Pharmacological effects of biotin. Journal of Nutritional Biochemistry. 2005 Aug; 16(7):424-7. https://www.ncbi.nlm.nih.gov/pubmed/15992683

50 Tourbah, A. et.al. MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, placebo-controlled study. Mult Scler. 2016 Nov;22(13):1719-1731. https://www.ncbi.nlm.nih.gov/pubmed/27589059

51 Heidker, RM et.al. Intersections of pathways involving biotin and iron relative to therapeutic mechanisms for progressive multiple sclerosis. Discov Med. 2016 Dec;22(123):381-387. https://www.ncbi.nlm.nih.gov/pubmed/28147220

52 McCarty, MF et.al. Neuroprotective potential of high-dose biotin. Med Hypotheses. 2017 Nov;109:145-149. https://www.ncbi.nlm.nih.gov/pubmed/29150274

53 Chen, S. et.al. Mechanism-based tumor-targeting drug delivery system. Validation of efficient vitamin receptor-mediated endocytosis and drug release. Bioconjug Chem. 2010 May 19;21(5):979-87. https://www.ncbi.nlm.nih.gov/pubmed/20429547

54 Kuroishi, T. Regulation of immunological and inflammatory functions by biotin. Can J Physiol Pharmacol. 2015 Dec;93(12):1091-6. https://www.ncbi.nlm.nih.gov/pubmed/26168302

55 Ericson, U. et.al. High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmö Diet and Cancer cohort. Am J Clin Nutr. 2007 Aug;86(2):434-43. https://www.ncbi.nlm.nih.gov/pubmed/17684216

56 Tio, M. et.al. Folate intake and the risk of upper gastrointestinal cancers: a systematic review and meta-analysis. J Gastroenterol Hepatol. 2014 Feb;29(2):250-8. https://www.ncbi.nlm.nih.gov/pubmed/24224911

57 Gules, O. et.al. Effects of folic acid on testicular toxicity induced by bisphenol-A in male Wistar rats. Biotech Histochem. 2018 Aug 6:1-10. https://www.ncbi.nlm.nih.gov/pubmed/30079777

58 De Regil, LM et.al.  Effects and safety of periconceptional oral folate supplementation for preventing birth defects. Cochrane Database Syst Rev. 2015 Dec 14;(12):CD007950. https://www.ncbi.nlm.nih.gov/pubmed/26662928

59 Huo, Y. Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: the CSPPT randomized clinical trial. JAMA. 2015 Apr 7;313(13):1325-35. https://www.ncbi.nlm.nih.gov/pubmed/25771069

60 Duman, N. et.al. Topical folinic acid enhances wound healing in rat model. Adv Med Sci. 2018 Aug 6;63(2):347-352. https://www.ncbi.nlm.nih.gov/pubmed/30092503

61 LeBlanc, DP et.al. Folate deficiency increases chromosomal damage and mutations in hematopoietic cells in the transgenic mutamouse model. Environ Mol Mutagen. 2018 Jun;59(5):366-374. https://www.ncbi.nlm.nih.gov/pubmed/29668043

62 Miller, A. et. al. Vitamin B12, demyelination, remyelination and repair in multiple sclerosis. Journal of the Neurological Sciences. 2015 Jun;233(1-2):93-97. https://www.jns-journal.com/article/S0022-510X(05)00087-0/fulltext

63 Thomas, S. et.al. Effect of Maternal Vitamin B12 Supplementation on Cognitive Outcomes in South Indian Children: A Randomized Controlled Clinical Trial. Matern Child Health J. 2018 Jul 12. https://www.ncbi.nlm.nih.gov/pubmed/30003521

64 Solomon, LR. Diabetes as a cause of clinically significant functional cobalamin deficiency. Diabetes Care. 2011 May;34(5):1077-80.https://www.ncbi.nlm.nih.gov/pubmed/21421801

65 Ankar, A. et.al. Vitamin, B12 (Cobalamin), Deficiency. StatPearls. 2017 Jun 20. https://www.ncbi.nlm.nih.gov/pubmed/28722952

66 Bram, D. et.al. Pernicious anemia presenting as catatonia: correlating vitamin B12 levels and catatonic symptoms. Gen Hosp Psychiatry. 2015 May-Jun;37(3):273.e5 7.  https://www.ncbi.nlm.nih.gov/pubmed/25774050

67 McCaddon, A. Vitamin B12 in neurology and ageing; clinical and genetic aspects. Biochimie. 2013 May;95(5):1066-76. https://www.ncbi.nlm.nih.gov/pubmed/23228515

68 Reynolds, E. Vitamin B12, folic acid, and the nervous system. Lancet Neurol. 2006 Nov;5(11):949-60. https://www.ncbi.nlm.nih.gov/pubmed/17052662

69 Johnston, CS et.al. Vitamin C supplementation slightly improves physical activity levels and reduces cold incidence in men with marginal vitamin C status: a randomized controlled trial. Nutrients. 2014 Jul 9;6(7):2572-83.  https://www.ncbi.nlm.nih.gov/pubmed/25010554

70 Pires, AS et.al. Ascorbic acid and colon cancer: an oxidative stimulus to cell death depending on cell profile. Eur J Cell Biol. 2016 Jun-Jul;95(6-7):208-18. https://www.ncbi.nlm.nih.gov/pubmed/27083410

71 Moretti, M. et.al. Preventive and therapeutic potential of ascorbic acid in neurodegenerative diseases. CNS Neurosci Ther. 2017 Dec;23(12):921-929. https://www.ncbi.nlm.nih.gov/pubmed/28980404

72 Carr, AC et.al. Vitamin C and Immune Function. Nutrients. 2017 Nov 3;9(11). https://www.ncbi.nlm.nih.gov/pubmed/29099763

73 Vaezipour, N. et.al. Nonalimental Scurvy With Relapse Symptoms After Stopping Oral Vitamin C Supplementation. Pediatrics. 2018 Aug;142(2). https://www.ncbi.nlm.nih.gov/pubmed/30065004

74 Vissers, MCM et.al. Potential Mechanisms of Action for Vitamin C in Cancer: Reviewing the Evidence. Front Physiol. 2018 Jul 3;9:809. https://www.ncbi.nlm.nih.gov/pubmed/30018566

75 Abdullah, M. et.al. Vitamin, C (Ascorbic Acid). StatPearls. 2018 May 21. https://www.ncbi.nlm.nih.gov/pubmed/29763052

76 Garland, C. The Role of Vitamin D in Cancer Prevention. Am J Public Health. 2006 February; 96(2): 252–261. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1470481/

77 Anglin, RE et al. Vitamin D deficiency and depression in adults: systematic review and meta-analysis. Br J Psychiatry. 2013 Feb;202:100-7. https://www.ncbi.nlm.nih.gov/pubmed/23377209/

78 Feng, J et al. Clinical improvement following vitamin D3 supplementation in Autism Spectrum Disorder. Nutr Neurosci. 2017 Jun;20(5):284-290. https://www.ncbi.nlm.nih.gov/pubmed/26783092

79 Brown, SJ. The role of vitamin D in multiple sclerosis. Ann Pharmacother. 2006 Jun;40(6):1158-61. https://www.ncbi.nlm.nih.gov/pubmed/16684809

80 Vieth, R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr. 1999 May;69(5):842-56.

81 Mirhosseini, N. et.al. Vitamin D Supplementation, Glycemic Control, and Insulin Resistance in Prediabetics: A Meta-Analysis. J Endocr Soc. 2018 May 25;2(7):687-709. https://www.ncbi.nlm.nih.gov/pubmed/29951596

82 Le, TYL et.al. Vitamin D Improves Cardiac Function After Myocardial Infarction Through Modulation of Resident Cardiac Progenitor Cells. Heart Lung Circ. 2018 Aug;27(8):967-975. https://www.ncbi.nlm.nih.gov/pubmed/29573957

83 Wikipedia, “Vitamin E.” Accessed 19 Aug 2018. https://en.wikipedia.org/wiki/Vitamin_E

84 La Fata, Giorgio et.al. Effects of Vitamin E on Cognitive Performance during Ageing and in Alzheimer’s Disease. Nutrients 2014, 6(12), 5453-5472 http://www.mdpi.com/2072-6643/6/12/5453/htm

85 Selvaraju, TR et.al. Cytoprotective Effect of Tocotrienol-Rich Fraction and α-Tocopherol Vitamin E Isoforms Against Glutamate-Induced Cell Death in Neuronal Cells. Int J Vitam Nutr Res. 2014;84(3-4):140-51. https://www.ncbi.nlm.nih.gov/pubmed/26098478

86 Meydani, M. et.al. Long-term vitamin E supplementation reduces atherosclerosis and mortality in Ldlr-/- mice, but not when fed Western style diet. Atherosclerosis. 2014 Mar;233(1):196-205. https://www.ncbi.nlm.nih.gov/pubmed/24529144

87 Galli, F. et.al. Vitamin E: Emerging aspects and new directions. Free Radic Biol Med. 2017 Jan;102:16-36. https://www.ncbi.nlm.nih.gov/pubmed/27816611

88 Montagnani Marelli, M. et.al. Anticancer properties of tocotrienols: A review of cellular mechanisms and molecular targets. J Cell Physiol. 2018 Aug 1. https://www.ncbi.nlm.nih.gov/pubmed/30066964

89 Selvaraju, TR. The neuroprotective effects of tocotrienol rich fraction and alpha tocopherol against glutamateinjury in astrocytes. Bosn J Basic Med Sci. 2014 Nov 16;14(4):195-204. https://www.ncbi.nlm.nih.gov/pubmed/25428670

90 La Fata, op.cit.

91 Wikipedia, “Vitamin K.” Accessed 19 Aug 2018. https://en.wikipedia.org/wiki/Vitamin_K

92 Anwar, F. et.al. Therapeutic role of calcium and vitamin K3 in chemically induced hepatocarcinogenesis – new tools for cancer treatment. Arch Physiol Biochem. 2018 Apr 17:1-6. https://www.ncbi.nlm.nih.gov/pubmed/29663832

93 Kluch, M. et.al. [The importance of diet in the prevention of adverse reactions to vitamin K-dependent anticoagulants]. Pol Merkur Lekarski. 2018 Jul 30;45(265):5-10. https://www.ncbi.nlm.nih.gov/pubmed/30058620

94 Ferland, G. Vitamin K, an emerging nutrient in brain function. Biofactors. 2012 Mar-Apr;38(2):151-7. https://www.ncbi.nlm.nih.gov/pubmed/22419547

95 Chatrou, ML et.al. Role of vitamin K-dependent proteins in the arterial vessel wall. Hamostaseologie. 2011 Nov;31(4):251-7. https://www.ncbi.nlm.nih.gov/pubmed/21713318

96 Ferland, op.cit.

97 Kaesler, N. et.al. Impaired vitamin K recycling in uremia is rescued by vitamin K supplementation. Kidney Int. 2014 Aug;86(2):286-93. https://www.ncbi.nlm.nih.gov/pubmed/24429407

98 Chatrou, op.cit.

99 Wikipedia, “Calcium.” Accessed 18 Aug 2018. https://en.wikipedia.org/wiki/Calcium

100 Merrilees, MJ et.al. Effects of diary food supplements on bone mineral density in teenage girls. Eur J Nutr. 2000 Dec;39(6):256-62. https://www.ncbi.nlm.nih.gov/pubmed/11395985

101 Gennari, C. Calcium and vitamin D nutrition and bone disease of the elderly. Public Health Nutr. 2001 Apr;4(2B):547-59. https://www.ncbi.nlm.nih.gov/pubmed/11683549

102 Baron, JA et.al. Calcium supplements for the prevention of colorectal adenomas. Calcium Polyp Prevention Study Group. N Engl J Med. 1999 Jan 14;340(2):101-7. https://www.ncbi.nlm.nih.gov/pubmed/9887161

103 Misiti, J. et.al. Erythropoiesis in vitro. Role of calcium. J Clin Invest. 1979 Dec;64(6):1573-9. https://www.ncbi.nlm.nih.gov/pubmed/115902

104 Adebamowo, SN et.al. Association between intakes of magnesium, potassium, and calcium and risk of stroke: 2 cohorts of US women and updated meta-analyses. Am J Clin Nutr. 2015 Jun;101(6):1269-77. https://www.ncbi.nlm.nih.gov/pubmed/25948665

105 Zhu, K. et.al. Calcium and bone. Clin Biochem. 2012 Aug;45(12):936-42. https://www.ncbi.nlm.nih.gov/pubmed/22609892

106 Vinarova, L. et.al. The mechanism of lowering cholesterol absorption by calcium studied by using an in vitro digestion model. Food Funct. 2016 Jan;7(1):151-63. https://www.ncbi.nlm.nih.gov/pubmed/26481461

107 Denoyer, D. et.al. Targeting copper in cancer therapy: ‘Copper That Cancer’. Metallomics. 2015 Nov;7(11):1459-76. https://www.ncbi.nlm.nih.gov/pubmed/26313539

108 Tavano-Colaizzi, L. et.al. The consumption of antioxidants protects against cognitive and physical disabilities in aged with obesity. Nutr Hosp. 2018 Jun 22;35(4):811-819. https://www.ncbi.nlm.nih.gov/pubmed/30070868

109 Medhat Hegazy, A. et.al. Protective and antioxidant effects of copper-nicotinate complex against glycerol-induced nephrotoxicity in rats. Drug Chem Toxicol. 2018 Jun 26:1-6. https://www.ncbi.nlm.nih.gov/pubmed/29944001

110 Wazir, SM et.al. Copper deficiency, a new triad: anemia, leucopenia, and myeloneuropathy. J Community Hosp Intern Med Perspect. 2017 Sep 19;7(4):265-268. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637704/

111 Zimnicka, AM et.al. Acquisition of dietary copper: a role for anion transporters in intestinal apical copper uptake. Am J Physiol Cell Physiol. 2011 Mar;300(3):C588-99. https://www.ncbi.nlm.nih.gov/pubmed/21191107

112 Antoniades, V. et.al. Is copper chelation an effective anti-angiogenic strategy for cancer treatment? Med Hypotheses. 2013 Dec;81(6):1159-63. https://www.ncbi.nlm.nih.gov/pubmed/24210000

113 Wang, Y. et.al. Maternal iodine supplementation improves motor coordination in offspring by modulating the mGluR1 signaling pathway in mild iodine deficiency-induced hypothyroxinemia rats. J Nutr Biochem. 2018 May 1;58:80-89. https://www.ncbi.nlm.nih.gov/pubmed/29886192

114 Olvera-Caltzontzin, P.  et.al. Iodine uptake and prostate cancer in the TRAMP mouse model. Mol Med. 2013 Nov 8;19:409-16. https://www.ncbi.nlm.nih.gov/pubmed/24306422

115 O’Kane, SM et.al. Micronutrients, iodine status and concentrations of thyroid hormones: a systematic review. Nutr Rev. 2018 Jun 1;76(6):418-431.https://www.ncbi.nlm.nih.gov/pubmed/29596650

116 Zimmermann, MB. Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: a review. Am J Clin Nutr. 2009 Feb;89(2):668S-72S. https://www.ncbi.nlm.nih.gov/pubmed/19088150

117 Zimmerman, op.cit.

118 Barbesino, G. Thyroid Function Changes in the Elderly and Their Relationship to Cardiovascular Health: A Mini-Review. Gerontology. 2018 Jul 20:1-8. https://www.ncbi.nlm.nih.gov/pubmed/30032140

119 Dahlerup, J. et.al. [Iron deficiency and iron deficiency anemia are global health problems]. Lakartidningen. 2015 Mar 10;112. https://www.ncbi.nlm.nih.gov/pubmed/25756711

120 Dahlerup, op.cit.

121 Rybinska, I et.al. Mutual Cross Talk Between Iron Homeostasis and Erythropoiesis. Vitam Horm. 2017;105:143-160. https://www.ncbi.nlm.nih.gov/pubmed/28629515

122 Dahlerup, op.cit.

123 Dong, JY et.al. Magnesium intake and risk of type 2 diabetes: meta-analysis of prospective cohort studies. Diabetes Care. 2011 Sep;34(9):2116-22. https://www.ncbi.nlm.nih.gov/pubmed/21868780

124 Sadeh, M. Action of magnesium sulfate in the treatment of preeclampsia-eclampsia. Stroke. 1989 Sep;20(9):1273-5. https://www.ncbi.nlm.nih.gov/pubmed/2672428

125 Gant, CM et.al. Higher Dietary Magnesium Intake and Higher Magnesium Status Are Associated with Lower Prevalence of Coronary Heart Disease in Patients with Type 2 Diabetes. Nutrients. 2018 Mar 5;10(3). https://www.ncbi.nlm.nih.gov/pubmed/29510564

126 Chiu, HY et.al. Effects of Intravenous and Oral Magnesium on Reducing Migraine: A Meta-analysis of Randomized Controlled Trials. Pain Physician. 2016 Jan;19(1):E97-112. https://www.ncbi.nlm.nih.gov/pubmed/26752497

127 Champagne, CM. Magnesium in hypertension, cardiovascular disease, metabolic syndrome, and other conditions: a review. Nutr Clin Pract. 2008 Apr-May;23(2):142-51. https://www.ncbi.nlm.nih.gov/pubmed/18390781

128 Volpe, SL. Magnesium in disease prevention and overall health. Adv Nutr. 2013 May 1;4(3):378S-83S. https://www.ncbi.nlm.nih.gov/pubmed/23674807

129 Kirkland, AE et.al. The Role of Magnesium in Neurological Disorders. Nutrients. 2018 Jun 6;10(6). https://www.ncbi.nlm.nih.gov/pubmed/29882776

130 Wikipedia, “Potassium.” Accessed 19 Aug 2018. https://en.wikipedia.org/wiki/Potassium

131 Binia, A. et.al. Daily potassium intake and sodium-to-potassium ratio in the reduction of blood pressure: a meta-analysis of randomized controlled trials. J Hypertens. 2015 Aug;33(8):1509-20. https://www.ncbi.nlm.nih.gov/pubmed/26039623

132 Udensi, UK et.al. Potassium Homeostasis, Oxidative Stress, and Human Disease. Int J Clin Exp Physiol. 2017;4(3):111-122. https://www.ncbi.nlm.nih.gov/pubmed/29218312

133 Bollag, WB. Regulation of aldosterone synthesis and secretion. Compr Physiol. 2014 Jul;4(3):1017-55. https://www.ncbi.nlm.nih.gov/pubmed/24944029

134 Fijorek, K. et.al. Serum potassium, sodium and calcium levels in healthy individuals – literature review and data analysis. Folia Med Cracov. 2014;54(1):53-70. https://www.ncbi.nlm.nih.gov/pubmed/25556366

135 Fijorek, op.cit.

136 Wikipedia, “Selenium.” Accessed 19 Aug 2018. https://en.wikipedia.org/wiki/Selenium

137 Zhang, S. et.al. Selenoproteins and the aging brain. Mech Ageing Dev. 2010 Apr;131(4):253-60. https://www.ncbi.nlm.nih.gov/pubmed/20219520

138 Kudva, AK et.al. Selenium and inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol. 2015 Jul 15;309(2):G71-7. https://www.ncbi.nlm.nih.gov/pubmed/26045617

139 Yakubov, E. et.al. Selenium action in neuro-oncology. Biol Trace Elem Res. 2014 Dec;161(3):246-54. https://www.ncbi.nlm.nih.gov/pubmed/25164034

140 Tsuji, PA et.al. Dietary Selenium Levels Affect Selenoprotein Expression and Support the Interferon-γ and IL-6 Immune Response Pathways in Mice. Nutrients. 2015 Aug 6;7(8):6529-49. https://www.ncbi.nlm.nih.gov/pubmed/26258789

141 Kudva, op.cit.

142 Chen, YC et.al. Is selenium a potential treatment for cancer metastasis? Nutrients. 2013 Apr 8;5(4):1149-68. https://www.ncbi.nlm.nih.gov/pubmed/23567478

143 Angstwurm, MW et.al. Selenium in Intensive Care (SIC): results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock. Crit Care Med. 2007 Jan;35(1):118-26. https://www.ncbi.nlm.nih.gov/pubmed/17095947

144 Berger, MM et.al. Trace element supplementation after major burns increases burned skin trace element concentrations and modulates local protein metabolism but not whole-body substrate metabolism. Am J Clin Nutr. 2007 May;85(5):1301-6. https://www.ncbi.nlm.nih.gov/pubmed/17490966

145 Barnett, JB et.al. Effect of zinc supplementation on serum zinc concentration and T cell proliferation in nursing home elderly: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2016 Mar;103(3):942-51. https://www.ncbi.nlm.nih.gov/pubmed/26817502

146 Aggarwal, R. et.al. Role of zinc administration in prevention of childhood diarrhea and respiratory illnesses: a meta-analysis. Pediatrics. 2007 Jun;119(6):1120-30. https://www.ncbi.nlm.nih.gov/pubmed/17545379

147 Sandusky-Beltran, LA et.al. Supplementation with zinc in rats enhances memory and reverses an age-dependent increase in plasma copper. Behav Brain Res. 2017 Aug 30;333:179-183. https://www.ncbi.nlm.nih.gov/pubmed/28693861

148 Wang, L. et.al. Efficacy of zinc given as an adjunct to the treatment of severe pneumonia: A meta-analysis of randomized, double-blind and placebo-controlled trials. Clin Respir J. 2018 Mar;12(3):857-864. https://www.ncbi.nlm.nih.gov/pubmed/28488366

149 Hemila, H. et.al. Zinc Acetate Lozenges May Improve the Recovery Rate of Common Cold Patients: An Individual Patient Data Meta-Analysis. Open Forum Infect Dis. 2017 Apr 3;4(2):ofx059. https://www.ncbi.nlm.nih.gov/pubmed/28480298

150 Norouzi, S. et.al. Zinc transporters and insulin resistance: therapeutic implications for type 2 diabetes and metabolic disease. J Biomed Sci. 2017 Nov 20;24(1):87. https://www.ncbi.nlm.nih.gov/pubmed/29157234