With the development of the very first vaccination of smallpox, brave anti-vaccinators fought against the dangerous, ill-advised practice of vaccinations. Those fighting against vaccines included the most intelligent and respected physicians of their time. 
This fight has been steadfast and continuous, as anti-vaccinators fought against an unjust, dangerous medical procedure. Vaccinations have always only profited the vaccine makers, not the people targeted for vaccines. Today’s anti-vaccination movement, while still in the minority, is most likely the largest we have had in history.
The smallpox vaccine was first developed in 1775, credited to Edward Jenner, who first experimented with an eight year-old boy named James Phipps. Jenner claimed that the procedure of injecting cowpox pus prevented smallpox and he convinced King George that his vaccine would eliminate smallpox. King George awarded Jenner the equivalent of half a million dollars to inoculate the public against smallpox.