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The Gary Null Show -08.26.20

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Potential effects of probiotics and omega 3 fatty acids on chronic low-grade inflammation

University of Orebro (Sweden), August 24, 2020

 

According to news reporting originating from Orebro, Sweden, by NewsRx correspondents, research stated, “Chronic low-grade inflammation negatively impacts health and is associated with aging and obesity, among other health outcomes.”

The news correspondents obtained a quote from the research from University of Orebro: “A large number of immune mediators are present in the digestive tract and interact with gut bacteria to impact immune function. The gut microbiota itself is also an important initiator of inflammation, for example by releasing compounds such as lipopolysaccharides (LPS) that may influence cytokine production and immune cell function. Certain nutrients (e.g., probiotics, o-3 fatty acids [FA]) may increase gut microbiota diversity and reduce inflammation. * * Lactobacilli* * and * * Bifidobacteria* * , among others, prevent gut hyperpermeability and lower LPS-dependent chronic low-grade inflammation. Furthermore, o-3 FA generate positive effects on inflammation-related conditions (e.g., hypertriglyceridemia, diabetes) by interacting with immune, metabolic, and inflammatory pathways. O-3 FA also increase LPS-suppressing bacteria (i.e., * * Bifidobacteria* * ) and decrease LPS-producing bacteria (i.e., * * Enterobacteria* * ).”

According to the news reporters, the research concluded: “Additionally, o-3 FA appear to promote short-chain FA production. Therefore, combining probiotics with o-3 FA presents a promising strategy to promote beneficial immune regulation via the gut microbiota, with potential beneficial effects on conditions of inflammatory origin, as commonly experienced by aged and obese individuals, as well as improvements in gut-brain-axis communication.”

 

 

Researchers argue health care systems should use ‘food as medicine’ interventions

University of North Carolina, August 25, 2020

An analysis recently published in the British Medical Journal argues for increased implementation of “food is medicine” interventions in the health care system. The article was co-authored by Seth A. Berkowitz, MD, MPH, assistant professor of medicine at the UNC School of Medicine, who mostly recently argued in the New England Journal of Medicine that food insecurity is known to be a health equity issue that disproportionately affects racial/ethnic minorities and those with lower incomes and rural communities. Thus, food insecurity is now playing a big role in the COVID-19 pandemic and associated health outcomes.

Berkowitz has conducted a number of studies on health-related social needs and their effect on health outcomes, published in JAMA Internal Medicine.

Sarah Downer, JD, from the Center for Health Law and Policy Innovation at Harvard Law School is the first author of the BMJ study, along with Timothy Harlan, MD, at the George Washington University School of Medicine and Health Sciences, Dana Lee Olstad, Ph.D., at the Cumming School of Medicine at University of Calgary, and Dariush Mozaffarian, MD, MPH, DrPH, from the Friedman School of Nutrition Science and Policy at Tufts University.

The world is facing an epidemic of diet-related chronic diseases with one in five deaths attributed to a suboptimal diet, more than any other risk factor including tobacco, according to the authors. An emerging body of research suggests that nutrition interventions delivered in the health care system may be associated with improved outcomes.

“Food is medicine” is an initiative around integrating specific food and nutrition interventions in, or closely coordinated with, the health care system. These interventions include medically tailored meals, medically tailored groceries, and produce prescriptions. According to the authors, clinicians should be knowledgeable enough to recognize a patient’s nutritional needs and understand the impact of available services. However, this is not the case in many countries, including the United States.

“Nutrition training delivered across disciplines holds the promise of more effective patient nutrition education and treatment,” the authors write. “Clinicians should have familiarity with validated nutrition assessment tools, the range of availability food is medicine interventions, and the systems and incentive structures that enable and encourage their use in clinical practice.”

The benefits of the approach include offering patients greater ability to follow dietary recommendations and alleviating budget constraints that might prevent them from affording medications or paying bills. They also suggest that with these interventions, clinicians might see better disease management and fewer hospital admissions.

“As health care systems continue to evolve to tackle the global crisis of nutrition related diseases, food is medicine interventions should be held to rigorous standards when decisions about implementation, coverage, and care are made,” the authors write. “Food as medicine can no longer be excluded as outside or ancillary to health care delivery.”

 

 

Meta-analysis adds evidence to chromium supplementation’s glucose control benefits in diabetics

Lorestan University of Medical Sciences (Iran), August 25, 2020

 

A systematic review and meta-analysis published on July 27, 2020 in Pharmacological Research found reductions in fasting plasma glucose, insulin, hemoglobin A1c (HbA1c, a marker of long term glucose control) and insulin resistance in men and women with type 2 diabetes who supplemented with the mineral chromium.

For their analysis, Omid Asbaghi of Lorestan University of Medical Sciences and colleagues selected 23 randomized, controlled trials that evaluated the effects of supplementing with chromium on various glycemic control indexes. Doses used in the studies ranged between 50 micrograms (mcg) and 1,000 mcg per day consumed from four to 25 weeks. Eleven of the trials evaluated a chromium dosage within a 400 to 600 mcg range.

Analysis of 22 trials that reported fasting plasma glucose levels concluded that chromium supplementation was associated with an average reduction of 19.0 milligrams per deciliter (mg/dL) in comparison with the placebo. Trials of at least 12 weeks duration were associated with a far greater average decrease of 58.74 mg/dL in association with chromium.

Of the 14 trials that reported insulin levels, levels declined by an average of 1.7784 µIU/mL among subjects who received chromium compared to the placebo, with trials that lasted 12 weeks or longer associated with a decrease of 3.47 µIU/mL.

For the 22 trials that reported HbA1c, supplementation with chromium was associated with an average decrease of 0.71%, which improved to a significant 1.70% reduction when trials of 12 weeks duration or more were examined. Homeostatic model assessment for insulin resistance (HOMA-IR) also decreased significantly among participants who received chromium.

The authors observed that chromium plays a role in carbohydrate and lipid metabolism and may enhance insulin sensitivity. Other nutrients that have been associated with a lower risk of type 2 diabetes include vitamins A, C, D and E, beta-carotene, calcium, magnesium, potassium and zinc.

“Present systematic review and meta-analysis of all available published randomized trials up to 2020 found a significant reduction in all glycemic control indices such as fasting plasma glucose, insulin, HbA1c and HOMA-IR levels after chromium supplementation,” they wrote. “Furthermore, long term intervention contributed to greater reduction of all mentioned indices.”

“The results of the current meta‐analysis study might support the use of chromium supplementation for the improvement of glycemic control indices in T2DM patients,” they concluded.

 

 

Children raised in greener areas have higher IQ, study finds

Research also found lower levels of difficult behavior in rich and poor neighborhoods

Hasselt University (Belgium), August 25, 2020

 

Growing up in a greener urban environment boosts children’s intelligence and lowers levels of difficult behaviour, a study has found.

The analysis of more than 600 children aged 10-15 showed a 3% increase in the greenness of their neighbourhood raised their IQ score by an average of 2.6 points. The effect was seen in both richer and poorer areas.

There is already significant evidence that green spaces improve various aspects of children’s cognitive development but this is the first research to examine IQ. The cause is uncertain but may be linked to lower stress levels, more play and social contact or a quieter environment.

The increase in IQ points was particularly significant for those children at the lower end of the spectrum, where small increases could make a big difference, the researchers said.

“There is more and more evidence that green surroundings are associated with our cognitive function, such as memory skills and attention,” said Tim Nawrot, a professor of environmental epidemiology at Hasselt University in Belgium, where the study was conducted.

“What this study adds with IQ is a harder, well-established clinical measure. I think city builders or urban planners should prioritise investment in green spaces because it is really of value to create an optimal environment for children to develop their full potential.”

he study, published in the journal Plos Medicine, used satellite images to measure the level of greenness in neighbourhoods, including parks, gardens, street trees and all other vegetation.

The average IQ score was 105 but the scientists found 4% of children in areas with low levels of greenery scored below 80, while no children scored below 80 in areas with more greenery.

The benefits of more greenery that were recorded in urban areas were not replicated in suburban or rural areas. Nawrot suggested this may be because those places had enough greenness for all children living there to benefit.

Behavioural difficulties such as poor attention and aggressiveness were also measured in the children using a standard rating scale, and the average score was 46. In this case, a 3% rise in greenery resulted in a two-point reduction in behavioural problems, in line with previous studies.

The researchers took into account the wealth and education levels of the children’s parents, largely ruling out the idea that families who are better placed to support children simply have more access to green space.

Higher levels of air pollution are known to impair intelligence and childhood development but this factor was also ruled out as an explanation.

Instead, the scientists suggested lower noise levels, lower stress – as found in other research on green space benefits – and greater opportunities for physical and social activities may explain the higher IQ scores.

Dr Mathew White, an environmental psychologist at Exeter University in the UK, who was not part of the study team, praised the quality of the research.

“I’m always wary of the term intelligence as it has a problematic history and unfortunate associations,” he said. “But, if anything, this study might help us move away from seeing intelligence as innate – it could be influenced by environment, and I think that is much more healthy.”

White said it was reasonable to suggest more exercise and less stress as reasons for the higher IQ scores. “But I’m not sure why general intelligence should be improved by these things,” he said. “My guess is the intelligence measures are really picking up a child’s ability to concentrate and stick at a task, which has been shown in green space studies before.”

A study of children living in Barcelona, published in 2015, showed more green space was associated with better working memory and attention.

The researchers in the new study were able to account for many of the factors likely to affect IQ but data on the type of green space was not available. Previous work has shown this can be important, with trees giving more benefit to child development than farmland or scrubland, for example.

The team also did not have information on where the pupils attended school but most Belgian children go to nearby schools.

Five more ways to boost brainpower

1. Exercise

The link between physical activity, endorphins, and improved mental healthhas been well documented. But now, exercise has been proven to increase brainpower, with researchers at the University of Texas earlier this year finding that aerobic exercise improves blood flow to regions in the brain associated with memory.

2. Foods

Certain foods, especially oily fish, nuts and even chocolate, have been linked to improved brain performance. Oily fish is packed with omega-3 fatty acids, while nuts are a great source of vitamin E, and dark chocolate is rich with antioxidants.

3. Power naps

A good excuse for a midday nap can be that it is justified as an effective method of transforming brainpower for the better. Researchers at the University of Bristol found that in a study of 16 participants, those who had taken a 90-minute nap before performing a set of tasks had improved responses and improvement in processing information.

4. Meditation

Yoga, meditation and other types of mindful activity have become increasingly popular over recent years. Regardless of the trend, meditation in particular has been found to have a variety of neurological benefits. For instance, researchers at the University of California in Los Angeles found that long-term meditation can help the brain combat the effects of ageing.

5. Positive thinking

Positive thoughts, affirmations, and even “manifesting” have been hailed as a way to change life for the better, with the latter even gaining the endorsement of both Gwyneth Paltrow and Oprah Winfrey. But such activities also have a positive effect on the brain, with research suggesting that positive and happy thoughts can stimulate the growth of nerve connections and even increase attentiveness.

D-ribose supplementation associated with reduction in delayed onset muscle soreness induced by exercise

Beijing Sport University (China), August 24, 2020

 

According to news reporting out of Beijing, People’s Republic of China, by NewsRx editors, research stated, “Previous investigations suggest that appropriate nutritional interventions may reduce delayed onset muscle soreness (DOMS). This study examined the effect of D-ribose supplementation on DOMS induced by plyometric exercise.”

Our news journalists obtained a quote from the research from Beijing Sport University, “For the purpose of inducing DOMS, 21 untrained male college students performed a lower-limb plyometric exercise session that involved 7 sets of 20 consecutive frog hops with 90-s of rest between each set. Muscle soreness was measured with a visual analogue scale 1-h before, 24-h after, and 48-h after exercise. Subjects were then randomly placed into the D-ribose group (DRIB, n=11) and the placebo group (PLAC, n=10) to assure equivalent BMI and muscle soreness. After a 14-d washout/recovery period, subjects performed the same exercise session, with DRIB ingesting a 200 ml solution containing 15 g D-ribose 1-h before, 1-h, 12-h, 24-h, and 36-h after exercise, and PLAC ingesting a calorically equivalent placebo of the same volume and taste containing sorbitol and b-cyclodextrin. Muscle soreness and isokinetic muscle strength were measured, and venous blood was assessed for markers of muscle damage and oxidative stress 1-h before, 24-h and 48-h after exercise. In DRIB, muscle soreness after 24-h and 48-h in the second exercise session were significantly lower (p <0.01) than was experienced in the first exercise session. In the second exercise, blood-related markers of muscle soreness, including creatine kinase, lactate dehydrogenase (LDH), myoglobin and malondialdehyde (MDA) in DRIB after 24-h were lower in DRIB after 24-h than in PLAC (MDA, p<0.05; rest outcomes, p<0.01). In addition, LDH and MDA in DRIB were significantly lower (p <0.01) after 24-h in DRIB than in PLAC. No difference was found in isokinetic muscle strength and oxidative stress markers, including superoxide dismutase and total antioxidant capacity, between DRIB and PLAC after 24-h and 48-h. D-ribose supplementation reduces muscle soreness, improves recovery of muscle damage, and inhibits the formation of lipid peroxides. Young adult males performing plyometric exercise are likely to realize a DOMS reduction through consumption of D-ribose in 15 g/doses both before (1-h) and after (1-h, 12-h, 24-h, 36-h) exercise.”

According to the news editors, the research concluded: “These results suggest that appropriately timed consumption of D-ribose may induce a similar alleviation of exercise-induced DOMS in the general public.”

 

Desperate Times for Pandemic Lead to… Ozone?

Case study in three patients with severe COVID-19 pneumonia

MedPage Today August 24, 2020

Three patients present to a hospital emergency department in Ibiza, Spain, with severe COVID-19 pneumonia and respiratory failure and are given an unproven — and possibly dangerous — treatment: oxygen-ozone (O2-O3) therapy — also called ozonated autohemotherapy, which has been used to treat gout and involves intravenous infusion of ozonated autologous whole blood.

The FDA has called ozone “a toxic gas with no known useful medical application.”Furthermore, in April 2020a federal court entered a permanent injunction halting a purported “ozone therapy” center in Dallas from offering unproven treatments for COVID-19, after the company claimed that the treatments were able to “eradicate” the virus and were 95% effective in preventing the illness even for individuals who had tested positive.

As described in this case report, published on Aug. 17, 2020, of three patients in Spain, the clinicians drew 200 mL of autologous whole blood from the antecubital vein into a standard plastic disposable blood collection bag (certified SANO3 bag) with 35 mL of anticoagulant citrate dextrose solution. The team enriched the blood with 200 mL of gas mixture O2-Owith an ozone concentration of 40 μg/mL obtained using an ozone generator with CE0120 certificate type IIb. This was followed by reinfusion of the ozonized blood using the same vein over approximately 10 minutes.

Patient 1

Patient 1, a 49-year-old man, body mass index (BMI) of 31, reported having 1 week of ongoing abdominal pain, and that over the course of the previous day he had increasing shortness of breath. Examination finds a soft abdomen with no distension.

Upon auscultation of his chest, clinicians noted bilateral crackles with reduced air entry and ordered a computed tomography (CT) scan of the chest and abdomen, which identified lung infiltrates in both lungs, compatible with COVID-19 pneumonia. Laboratory tests show elevated levels of:

  • Ferritin (1,609 ng/mL)
  • D-dimer (1,900 ng/dL)
  • C-reactive protein (CRP, 17.3 mg/dL)
  • Lactate dehydrogenase (LDH, 536 IU/L)

Clinicians took a nasopharyngeal swab; real-time polymerase chain reaction (RT-PCR) analysis identified the sample as positive for viral RNA, and the man is admitted to the intensive care unit (ICU). Over the following 24 hours, his condition improves and he is transferred to the general ward.
However, during the following day, the patient’s oxygen levels declined, followed by respiratory distress, with a PaO2/FiO2 [partial pressure of arterial oxygen/percentage of inspired oxygen] ratio of 235. Clinicians put the patient on a non-rebreather face mask with oxygen on FiO2 of 0.8, and noninvasive ventilation (NIV) is not required. An x-ray revealed diffuse bilateral infiltrates.

For the next 3 days, the patient received two sessions of ozone autohemotherapy daily q 12 hours. He had a rapid clinical response, as evidenced by a marked improvement in respiratory rate and an increased PaO2/FiO2 ratio, with decreased FiO2 to 0.31% (3 L) after 1 day. After 2 sessions of ozone therapy, the patient’s ferritin levels dropped from over 2,000 to 246 ng/mL, and his D-dimer levels dropped from 1,900 to 323 ng/mL.

On day 4, the patient was discharged home.

 

Patient 2 

The second patient, a 61-year-old man, BMI of 29, presented a week after developing a persistent fever of over 39°C. He reported having long-standing hypertension and becoming progressively short of breath over the previous 2 days. Chest auscultation showed crackles with reduced air entry over the right hemithorax. CT of the chest–abdomen revealed right upper infiltrates suggestive of COVID-19 pneumonia. Baseline PaO2/FiO2 was 253.

Laboratory tests showed high levels of:

  • Ferritin (2,200 ng/mL)
  • D-dimer (3,660 ng/mL)
  • CRP (10 mg/dL)
  • LDH (816 IU/L)

The patient remained in the general ward, where he received oxygen at an FiO2 of 0.6 via face mask, and he did not require NIV.

For the following 2 days, he received two sessions of ozone autohemotherapy over a period of 24 hours. On day 3, clinicians noted a decline in the FiO2 of 0.31% (3 L) with improved PaO2 to 90 mmHg, and decreased levels of laboratory markers.

The patient was discharged home on day 3 after a total of four sessions of O2-O3therapy. Post-discharge, clinicians reported that the patient’s LDH levels dropped from 816 U/L at baseline to 469 U/L by day 6 after the start of ozone therapy. Likewise, his CRP levels began falling progressively after initiation of ozone therapy, from 10 mg/dL at the time of presentation to approximately 4 mg/dL on day 3 and about 0 mg/dL on day 21.

 

 

Nicotinamide riboside increases aerobic performance in mice

State University of Campinas (Brazil), August 19, 2020

 

According to news originating from Limeira, Brazil, by NewsRx correspondents, research stated, “Nicotinamide riboside (NR) acts as a potent NAD precursor and improves mitochondrial oxidative capacity and mitochondrial biogenesis in several organisms. However, the effects of NR supplementation on aerobic performance remain unclear.”

Our news journalists obtained a quote from the research from the State University of Campinas (UNICAMP), “Here, we evaluated the effects of NR supplementation on the muscle metabolism and aerobic capacity of sedentary and trained mice. Male C57BL/6 J mice were supplemented with NR (400 mg/Kg/day) over 5 and 10 weeks. The training protocol consisted of 5 weeks of treadmill aerobic exercise, for 60 min a day, 5 days a week. Bioinformatic and physiological assays were combined with biochemical and molecular assays to evaluate the experimental groups. NR supplementation by itself did not change the aerobic performance, even though 5 weeks of NR supplementation increased NAD levels in the skeletal muscle. However, combining NR supplementation and aerobic training increased the aerobic performance compared to the trained group. This was accompanied by an increased protein content of NMNAT3, the rate-limiting enzyme for NAD + biosynthesis and mitochondrial proteins, including MTCO1 and ATP5a. Interestingly, the transcriptomic analysis using a large panel of isogenic strains of BXD mice confirmed that the Nmnat3 gene in the skeletal muscle is correlated with several mitochondrial markers and with different phenotypes related to physical exercise. Finally, NR supplementation during aerobic training markedly increased the amount of type I fibers in the skeletal muscle.”

According to the news editors, the research concluded: “Taken together, our results indicate that NR may be an interesting strategy to improve mitochondrial metabolism and aerobic capacity.”

 

The warning signs of a magnesium deficiency

NaturalHealth360, August 22, 2020

As a macronutrient crucial to good health, magnesium is no slouch. This powerful mineral takes part in about 300 enzyme activities going on in your body, impacting everything from protein synthesis to blood pressure regulation.

Magnesium is also vital to a number of energy-related functions, earning it the reputation as the body’s ‘energizer’. Surprising, to most people, magnesium is responsible for:

  • Bone development
  • Synthesis of DNA, RNA and the antioxidant glutathione
  • Plus, the active transport of potassium and calcium ions across cellular membranes, which is critical to such bodily functions as muscle contraction, nerve impulse conduction, and proper heart rhythm.

What are the warning signs of magnesium deficiency?

When your body is short of magnesium for an extended period of time, it takes a toll on your health. Signs of a magnesium deficiency include anxiety, irritability, weakness and fatigue, as well as a general feeling of energy depletion.

Many health experts warn that if you experience:

  • Ringing in the ears or hearing loss
  • Unexplained muscle cramps or tremors
  • Depression
  • Abnormal heart function
  • Or, kidney stones

You may be magnesium deficient. While these symptoms may seem vague, they shouldn’t be ignored and when other health concerns are ruled out, magnesium deficiency should be suspect.

While fatigue may be the prevailing symptom, a magnesium deficiency can wreak havoc inside your body. Research has shown that lowered levels of magnesium can cause red blood cells to become fragile, meaning fewer available to deliver much-needed oxygen to the body’s tissues.

In addition to red blood cell issues depleting the body of energy, lowered magnesium levels can decrease your body’s efficiency at using stored energy and optimizing calorie burn.  In addition, those with lower magnesium levels often experience a greater need for oxygen and an increased heart rate when exercising.

Because of its role in maintaining bone structure, magnesium deficiency has also been linked to brittle bones and osteoporosis, while its role in glycolysis can promote further insulin resistance among those suffering from diabetes and related metabolic disorders when insufficient levels are available.

Energize yourself by increasing your magnesium levels

The recommended daily allowance (RDA) for magnesium in adults over 30 is 420 mg/day for men and 320 mg/day for women. Young adults should get about 400 mg/day for men and 310 mg/day for women.

And, while magnesium is widely available in leafy green vegetables, cereals and fruits, it’s estimated that between 68 and 75 percent of adults in the United States are magnesium deficient.

A diet rich in magnesium is the best way to ensure enough magnesium for optimal health, allowing for vital metabolic function, and promoting healthy bone structure and cardiovascular health.

Try to get five servings daily of magnesium rich foods, such as organic pumpkin seeds, sesame seeds, Brazil nuts, Swiss chard and kale.  Getting adequate magnesium through the foods you eat provides a more steady supply of this vital macronutrient.

This is important since your body is frequently using its stores of magnesium – especially people with an active lifestyle.

Due to modern farming techniques, mineral-deprived soil quality and the consumption of processed foods – most people are getting only around 200 mg. of magnesium per day from their meals.  Dr. Norman Shealy, MD, PhD – an American neurosurgeon and a pioneer in pain medicine – says, “every known illness is associated with a magnesium deficiency.”