GaryC

The Gary Null Show Notes – 07.30.21

  1. Investigation: How the Meat Industry is Climate-Washing its Polluting Business Model

  2. The CDC’s Hysterical Delta Flip-Flop Might Be Its Final Undoing

  3. America’s (Likely) Violent Future

  4. ‘Turn This Destruction Around’: 5 Months Left in 2021 But Humanity’s Used Up Earth’s Ecological Budget 

  5. Amazon Is Creating Company Towns Across the United States

  6. AstraZeneca’s having second thoughts about its COVID vaccine business as FDA filing drags on 

  7. Half of U.S. parents may not vaccinate their youngest child against Covid-19

    Todays Videos:

1. The Vaccine Causes The Virus To Be More Dangerous Steve Bannon edited out 10 mins

2. Ana Garner Interview

CoQ10 and nicotinamide adenine dinucleotide may aid chronic fatigue syndrome in women

Universitat Autònoma de Barcelona (Spain), July 28, 2021

Researchers from Spain found that CoQ10 plus nicotinamide adenine dinucleotide (NAD) supplementation for 8 weeks is safe and potentially effective in reducing max heart rate among chronic fatigue syndrome patients.

In a pilot eight-week, randomized, controlled, double-blind trial on 80 women with chronic fatigue syndrome, researchers found that supplementation of coenzyme Q10 with nicotinamide adenine dinucleotide (NAD) was able to reduce maximum heart rate more than a placebo.

The researchers are building on an earlier study, which suggested that “there is a mitochondrial failure which reduces the rate of adenosine-5-triphosphate (ATP) synthesis, the central agent of energy production in most chronic fatigue syndrome patients.”

Hence, because of prior evidence that CoQ10 and NAD can increase cellular ATP production via mitochondrial oxidative phphorylation, the researchers hypothesize that supplementation with the two coenzymes “could help improve fatigue and other symptoms in chronic fatigue syndrome,” they wrote.

“The data regarding the effects of CoQ10 and NADH supplementation on exercise performance and cardinal symptoms in [chronic fatigue syndrome] remain limited and inconsistent,”they added.

“Additionally, no specific assessment of cardiovascular functioning with CoQ10 plus NAD supplementation during a stress test in [chronic fatigue syndrome] has been performed to date.”

Selecting participants

“Since [chronic fatigue syndrome] is more prevalent in women we preferred to study a more homogeneous and representative sample,” the researchers wrote.

A total of 80 participants who met the criteria were then randomized in a double-blind manner, divided in two groups to receive either the CoQ10 and NAD supplement or placebo (with 40 participants in each group). Participants were instructed to refrain from taking other supplements containing CoQ10, NAD, phosphatidylserine, and vitamin C throughout the period of study.

The supplement group ingested four enteric-coated tablets daily for eight weeks. The supplement tablets contained active ingredients (50 mg of CoQ10 and 5 mg of NAD) and excipients (20 mg of phosphatidylserine and 40 mg of vitamin C), donated by Vitae Natural Nutrition Corporation, who also provided some financial support for the study.

Study design

On weeks four and eight, the participants self-reported changes in fatigue, pain, and sleep problems through questionnaires.

The patients were evaluated at baseline and at the end of the period on week eight for their predicted max heart rate functional response with an incremental cycle ergometer test. “The subjects performed a cycle ergometer test against a graded increase in workload, until exhaustion was reached,” the researchers wrote.

The researchers treated the reduction of maximum heart rate post exercise as an indicator for the supplement’s efficacy, as hearts of trained individuals, such as athletes, tend to beat less frequently because more blood is pumped with each beat.

Observations and results

Based on the two analysis criteria—questionnaires on changes in feeling and maximum heart rate based on cycle test—the researchers found that the supplement group participants had a greater maximum heart rate reduction after cycling in week eight compared to the placebo group.

Based on the questionnaires, participants in the supplement group also perceived less fatigue than the placebo group, but there were no statistically significant differences for pain perception and sleep disruption between the two groups.

“In conclusion, [study] suggested that the CoQ10 plus NAD supplementation may be a safe, well tolerated and potentially useful treatment,” the researchers wrote, highlighting that there were no adverse effects from combining the two coenzymes together, which they claimed had not been observed before.

“Larger multicenter trials with longer term follow-up interventions in more homogenous chronic fatigue syndrome populations are warranted to assess these findings and to produce evidence-based guidelines regarding the potential benefits of antioxidant therapy in chronic fatigue syndrom and other chronic conditions,” they added.

Boron-containing compound acts on multiple targets against Alzheimer disease

University of Salerno (Italy), July 24, 2021

According to news reporting out of Fisciano, Italy, research stated, “Given the multifactorial nature and pathogenesis of Alzheimer’s disease, therapeutic strategies are addressed to combine the benefits of every single-target drug into a sole molecule. Quantum mechanics and molecular dynamics (MD) methods were employed here to investigate the multitarget action of a boron-containing compound against Alzheimer’s disease.”

Our news journalists obtained a quote from the research from the University of Salerno, “The antioxidant activity as a radical scavenger and metal chelator was explored by means of density functional theory. The most plausible radical scavenger mechanisms, which are hydrogen transfer, radical adduct formation, and single-electron transfer in aqueous and lipid environments, were fully examined. Metal chelation ability was investigated by considering the complexation of Cu(II) ion, one of the metals that in excess can even catalyze the b-amyloid (Ab) aggregation. The most probable complexes in the physiological environment were identified by considering both the stabilization energy and the shift of the l induced by the complexation.”

According to the news editors, the research concluded: “The excellent capability to counteract Ab aggregation was explored by performing MD simulations on protein-ligand adducts, and the activity was compared with that of curcumin, chosen as a reference.”

This research has been peer-reviewed.

Healthy lifestyle may help mitigate high genetic risk of cancer

Nanjing Medical University (China), July 27, 2021

Background: As genetic research continues to uncover loci, or areas in DNA, with specific changes that influence cancer risk, researchers can define polygenic risk scores (PRS)—personalized estimates of an individual’s cancer risk—based on a patient’s unique combination of these changes. However, most PRS are generated for a specific cancer type, rather than for overall cancer risk.

“A PRS indicating risk of a certain cancer is important but not enough,” Jin said. “We tried to create an indicator—the cancer polygenic risk score (CPRS)—to measure the genetic risk of cancer as a whole.”

How the Study Was Conducted: Jin and colleagues calculated individual PRS for 16 cancers in men and 18 cancers in women, using available data from genome-wide association studies. They then used statistical methods to combine these scores into a single measure of cancer risk, based on the relative proportion of each cancer type in the general population. Separate CPRS were generated for men and women.

To validate their CPRS, the researchers utilized genotype information from 202,842 men and 239,659 women from the UK Biobank, a cohort of general-population participants recruited from England, Scotland, and Wales between 2006 and 2009, and calculated a CPRS for each individual.

UK Biobank participants were surveyed upon enrollment for various lifestyle factors, including smoking and alcohol consumption, body mass index, exercise habits, and typical diet. Based on these factors, Jin and colleagues classified each patient as having an unfavorable (zero to one healthy factors), intermediate (two to three healthy factors), or favorable (four to five healthy factors) overall lifestyle.

Results: Patients with the highest quintile CPRS were nearly twice as likely (for men) and 1.6 times as likely (for women) to have a cancer diagnosis by their most recent follow-up, in 2015 or 2016. Notably, 97 percent of patients in the study had a high genetic risk (top quintile) of at least one cancer type. “This suggests that almost everyone is susceptible to at least one type of cancer,” Jin said. “It further indicates the importance of adherence to a healthy lifestyle for everyone.”

Patients with an unfavorable lifestyle and the highest quintile genetic risk were 2.99 times (in men) and 2.38 times (in women) more likely to develop cancer than those with a favorable lifestyle and the lowest quintile of genetic risk.

Among patients with high genetic risk, the five-year cancer incidence was 7.23 percent in men and 5.77 percent in women with an unfavorable lifestyle, compared with 5.51 percent in men and 3.69 percent in women with a favorable lifestyle. The decreased percentages are comparable to the cancer risk in individuals with intermediate genetic risk, Jin said. Similar trends were observed in all genetic risk categories, suggesting that patients could benefit from a healthy lifestyle regardless of genetic risk.

Lower risk of diabetes found in green tea drinkers

Peking University, July 26 2021. 

The July 2021 issue of the American Journal of Clinical Nutrition reported a lower risk of developing diabetes as well as a decreased risk of mortality among those with pre-existing diabetes in association with daily intake of green tea.

Jia Nie and colleagues evaluated data from 26,162 diabetics and 461,074 nondiabetics who were between the ages of 30 and 79 years upon enrollment in the China Kadoorie Biobank. Questionnaire responses obtained at enrollment provided information concerning type and quantity of tea consumed.

Nondiabetic participants were followed for an 11.1-year median period, during which 17,434 cases of type 2 diabetes were diagnosed. The risk of developing diabetes was 3% lower among daily tea drinkers compared to those who reported no tea consumption during the previous year. Consuming tea every day for at least 30 years was associated with a 9% lower diabetes risk, and drinking green tea daily was associated with an 8% reduction.

Among diabetics, 6,572 deaths occurred during a 10.6-year median. Diabetics who drank green tea daily had a 10% lower risk of mortality than those who did not drink tea. Consuming tea daily for 10-29 years was associated with an 18% lower mortality risk. When causes of death were examined, diabetics who consumed tea every day had a 14% lower risk of cardiovascular mortality.

“To the best of our knowledge, this is by far the largest prospective cohort study that comprehensively investigated the association of tea consumption with long-term risk of type 2 diabetes and risk of death and complications among patients with diabetes,” the authors announced. “Daily green tea consumption was associated with a lower risk of incident type 2 diabetes and a lower risk of all-cause mortality in patients with diabetes, but the associations for other types of tea were less clear.”

Iodine supplement initiated prepregnancy associated with improved thyroid function in mildly-to-moderately iodine-deficient women

Institute of Marine Research (Norway), July 23, 2021

According to news originating from Bergen, Norway,  research stated, “Whereas the adverse effects of severe iodine deficiency during pregnancy are well documented, the effects of mild-to-moderate deficiency are not well established. We aimed to explore whether iodine nutrition and timing of iodine supplement initiation are associated with thyroid function in pregnant and postpartum women.”

Our news journalists obtained a quote from the research from the Institute of Marine Research, “In this cohort study, 137 pregnant women were enrolled and followed up at gestational weeks (GWs) 18 and 36, and 3 and 6 mo postpartum. Thyroid function tests [thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4)], urinary iodine and creatinine concentration (UIC:Cr), and iodine intake (including iodine supplement use) were measured at each time point. The associations between thyroid hormone concentrations and UIC:Cr, iodine intakes, and iodine supplement use were estimated using multiple generalized estimating equation models. The median UIC at GW18 was 94 mg/L, indicating mild-to-moderate iodine deficiency. UIC:Cr (b; 95% CI) per 100 mg/g was negatively associated with fT3 (-0.191; -0.331, -0.051) and fT4 (-0.756; -1.372, -0.141) concentrations. Iodine intake (b; 95% CI) per 100 mg/d was positively associated with TSH (0.099; 0.022, 0.177), and negatively associated with fT3 (-0.084; -0.0141, -0.027) and fT4 (-0.390; -0.599, -0.182) concentrations. Compared with no use of supplement, those initiating an iodine-containing supplement prepregnancy and continuing through pregnancy had lower TSH (estimated means) (1.35 compared with 1.68 mIU/L, P = 0.021), and higher fT3 (4.48 compared with 4.28 pmol/L, P = 0.035) and fT4 (15.2 compared with 14.4 pmol/L, P = 0.024) concentrations. Lower iodine availability during pregnancy and postpartum was associated with lower TSH, and higher fT3 and fT4 concentrations. The use of an iodine-containing supplement that was initiated prepregnancy and continuing through pregnancy was associated with lower TSH, and higher fT3 and fT4 concentrations, which may suggest improved thyroid function.”

According to the news editors, the research concluded: “These findings support the notion that optimization of iodine intake should start before pregnancy.This trial was registered at clinicaltrials.gov as NCT02610959.”

This research has been peer-reviewed.

A Single Session of Exercise Alters 9,815 Molecules in Our Blood

Stanford University, July 29, 2021

When we exercise, the levels of thousands of substances in our bloodstream rise and drop, according to an eye-opening new studyof the immediate, interior impacts of working out. The study is the most comprehensive cataloging to date of the molecular changes that occur during and after exercise and underscores how consequential activity — and inactivity — may be for our bodies and health.

Already, of course, we have reams of evidence that exercise alters our metabolisms, muscles, genes, immune responses, hearts, stamina and almost every other organ and biological system within us. But only in recent years, with the development of sophisticated new techniques for counting and typing the thousands upon thousands of different molecules within us, have scientists been able to quantify more of the substances and steps involved in those processes.

With these techniques, they have zeroed in on various sets of molecules in our bloodstreams associated with different aspects of our biology. This research generally is known as “omics” science. Metabolomics, for instance, enumerates and analyzes molecules in our blood that influence metabolism — everything from appetite hormones to enzymes excreted by gut microbes. Genomics maps the molecules involved in gene expression; proteomics ditto for proteins; lipidomics for fat-related molecules; and so on.

Recently, many studies have looked into particular ’omics affected by exercise. Almost all have focused on one arena, such as metabolomics or genomics and usually exclusively in people who are healthy and fit or those who are not.

But for the new study, which was published in May in Cell, scientists at Stanford University and other institutions decided to try to complete a full census of almost every molecule that changes when we work out.

This undertaking is daunting, but these researchers already had been quantifying the various ’omics of a group of about 100 adult men and women and knew a great deal about their health and fitness. Now, they chose 36 of them, representing an age range between 40 and 75 and a full spectrum of fitness and metabolic health. Some were in good aerobic condition, others out of shape, and some displayed fine blood-sugar control, while others were insulin resistant.

The researchers drew blood from each volunteer and then asked them to complete a standard treadmill endurance test, running at an increasing intensity until exhaustion, usually after about nine or 10 minutes of exercise. The researchers drew more blood immediately after this exertion and again 15, 30 and 60 minutes later. Later, they also drew blood from some of the volunteers before and after they had quietly rested, as a control measure.

Then they started counting and characterizing a boggling quantity of molecules in each person’s blood. They looked for molecules that were known to change when people exercise, but also for any that might not have been examined in previous exercise studies but were showing up in people’s blood now.

They wound up measuring the levels of 17,662 different molecules. Of these, 9,815 — or more than half — changed after exercise, compared to their levels before the workout. Some increased. Others declined. Some gushed immediately after the exercise, then fell away, while others lingered in heightened or lowered amounts for an hour after the workout.

The types of molecules also ranged widely, with some involved in fueling and metabolism, others in immune response, tissue repair or appetite. And within those categories, molecular levels coursed and changed during the hour. Molecules likely to increase inflammation surged early, then dropped, for instance, replaced by others likely to help reduce inflammation.

“It was like a symphony,” says Michael Snyder, the chair of the genetics department at Stanford University and senior author of the study. “First you have the brass section coming in, then the strings, then all the sections joining in.”

Interestingly, though, different people’s blood followed different orchestrations. Those who showed signs of insulin resistance, a driver of diabetes, for instance, tended to show smaller increases in some of the molecules related to healthy blood sugar control and higher increases in molecules involved in inflammation, suggesting that they were somewhat resistant to the general, beneficial effects of exercise. The levels of other molecules ranged considerably in people, depending on their current aerobic fitness.

Over all, the researchers were taken aback by the magnitude of the changes in people’s molecular profiles after exercise, Dr. Snyder says. “I had thought, it’s only about nine minutes of exercise, how much is going to change? A lot, as it turns out.”

This study was small, though, and looked at a single session of aerobic exercise, so cannot tell us anything about the longer-term molecular effects of continued training or of how, precisely, changes in molecular levels subsequently alter health. It also did not include young volunteers under 40.

Dr. Snyder and his colleagues are planning follow-up experiments with more volunteers and sustained exercise programs. They hope to establish whether certain molecular responses to exercise might distinguish people who would benefit from emphasizing resistance exercise over endurance training and whether specific molecular profiles indicate who has higher or lower aerobic endurance. This information could allow physicians and researchers to check fitness with a simple blood draw instead of a treadmill stress test.

International Tree Nut Council study finds link between nut intake and inflammatory biomarkers

Brigham and Women’s Hospital and Harvard Medical School, July 27, 2021

 

In a cross-sectional analysis published online in the American Journal of Clinical Nutrition*, researchers looked at the association between habitual nut consumption and inflammatory biomarkers among 5,013 men and women participating in two ongoing prospective cohort studies: the Nurses’ Health Study and Health Professionals Follow-up Study. Higher nut intake (5 or more times per week) was associated with lower levels of C-reactive protein (CRP) and Interleukin 6 (IL6). Both of these compounds increase in the body when there is inflammation, which can lead to chronic disease.

According to Ying Bao, MD, ScD, from the Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, and the senior author of the paper, “Substituting three servings per week of tree nuts for three servings per week of red meat, processed meat, or eggs was associated with significantly lower CRP (all P<0.0001) and IL6 (P ranges from 0.01 to 0.04); lower CRP concentrations were also observed when substituting three servings per week of tree nuts for refined grains (P=0.0008).” Elevated CRP levels have been shown to predict the development of both cardiovascular disease and type 2 diabetes, and IL6 has been associated with cardio-metabolic risk.

Previous research has shown that consuming tree nuts can help reduce the risk of cardiovascular disease and type 2 diabetes. Nuts contain a number of important components such as magnesium, fiber, antioxidants and unsaturated fatty acids–all of which may aid in protecting against inflammation.

Interestingly, research has also shown that nut consumption may be inversely related to body mass index (BMI), which is a strong determinant of inflammatory biomarkers. In fact, weight loss has been repeatedly shown to be associated with a decrease in levels of inflammatory biomarkers. Therefore, the researchers suggest, the associations between nut intake and inflammatory markers may be mediated in part through BMI.

“This is yet another piece of evidence showing that people should include more nuts in their diet,” states Maureen Ternus, M.S., R.D., Executive Director of the International Tree Nut Council Nutrition Research & Education Foundation (INC NREF). “Just a handful of tree nuts (1.5 ounces or 1/3 cup) every day can result in numerous health benefits.”